ORIGINAL ARTICLE: Testis Specific Lactate Dehydrogenase as Target for Immunoliposomes
Identifieur interne : 001978 ( Main/Exploration ); précédent : 001977; suivant : 001979ORIGINAL ARTICLE: Testis Specific Lactate Dehydrogenase as Target for Immunoliposomes
Auteurs : Ranjna C. Dutta ; Erwin Goldberg [États-Unis]Source :
- American Journal of Reproductive Immunology [ 1046-7408 ] ; 2008-07.
English descriptors
- Teeft :
- American journal, Antibody titer, Authors journal compilation, Binding association, Blackwell munksgaard, Blackwell munksgaard immunoliposome, Capacitated, Capacitated spermatozoa, Control liposome, Control liposomes, Dutta, Elisa, Human cancer, Immunoliposome, Immunoliposome binding, Immunoliposome preparation, Immunoliposomes, Immunology, Journal compilation, Liposome, Liposome concentration, Lmol, Munksgaard, Photon, Photon count, Photon counts, Relative binding, Reproductive, Reproductive immunology, Sephadex column, Single isomer, Sperm, Spermatozoon, Splice variants, Testis, Tissue distribution, Total counts.
Abstract
Problem Is it possible to deliver therapeutic agents to testis through specific targeting? Method of study Immunoliposomes are designed by incorporating antibodies to lactate dehydrogenase‐C4 (LDH‐C4), which is the product of a testis specific gene. Their targeting and delivering ability is investigated in vitro and in vivo. Results It is observed that LDHC4‐immunoliposomes are able to discriminate and recognize antigens on spermatozoa and testes both in vitro and in vivo. Conclusion Specific targeting through LDH‐C4 appears to be a feasible strategy for delivering therapeutic as well as anti‐spermatogenic agents to testis.
Url:
DOI: 10.1111/j.1600-0897.2008.00587.x
Affiliations:
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Dutta</name></author><author><name sortKey="Goldberg, Erwin" sort="Goldberg, Erwin" uniqKey="Goldberg E" first="Erwin" last="Goldberg">Erwin Goldberg</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, Molecular Biology and Cell Biology Northwestern University, Evanston, IL</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">American Journal of Reproductive Immunology</title><title level="j" type="alt">AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY</title><idno type="ISSN">1046-7408</idno><idno type="eISSN">1600-0897</idno><imprint><biblScope unit="vol">60</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="26">26</biblScope><biblScope unit="page" to="32">32</biblScope><biblScope unit="page-count">7</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2008-07">2008-07</date></imprint><idno type="ISSN">1046-7408</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1046-7408</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>American journal</term><term>Antibody titer</term><term>Authors journal compilation</term><term>Binding association</term><term>Blackwell munksgaard</term><term>Blackwell munksgaard immunoliposome</term><term>Capacitated</term><term>Capacitated spermatozoa</term><term>Control liposome</term><term>Control liposomes</term><term>Dutta</term><term>Elisa</term><term>Human cancer</term><term>Immunoliposome</term><term>Immunoliposome binding</term><term>Immunoliposome preparation</term><term>Immunoliposomes</term><term>Immunology</term><term>Journal compilation</term><term>Liposome</term><term>Liposome concentration</term><term>Lmol</term><term>Munksgaard</term><term>Photon</term><term>Photon count</term><term>Photon counts</term><term>Relative binding</term><term>Reproductive</term><term>Reproductive immunology</term><term>Sephadex column</term><term>Single isomer</term><term>Sperm</term><term>Spermatozoon</term><term>Splice variants</term><term>Testis</term><term>Tissue distribution</term><term>Total counts</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Problem Is it possible to deliver therapeutic agents to testis through specific targeting? Method of study Immunoliposomes are designed by incorporating antibodies to lactate dehydrogenase‐C4 (LDH‐C4), which is the product of a testis specific gene. Their targeting and delivering ability is investigated in vitro and in vivo. Results It is observed that LDHC4‐immunoliposomes are able to discriminate and recognize antigens on spermatozoa and testes both in vitro and in vivo. Conclusion Specific targeting through LDH‐C4 appears to be a feasible strategy for delivering therapeutic as well as anti‐spermatogenic agents to testis.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Illinois</li></region></list><tree><noCountry><name sortKey="Dutta, Ranjna C" sort="Dutta, Ranjna C" uniqKey="Dutta R" first="Ranjna C." last="Dutta">Ranjna C. Dutta</name></noCountry><country name="États-Unis"><region name="Illinois"><name sortKey="Goldberg, Erwin" sort="Goldberg, Erwin" uniqKey="Goldberg E" first="Erwin" last="Goldberg">Erwin Goldberg</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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